Flames first broke out at a property on Cameron Circle in Laurel Springs at 9 p.m. on Tuesday.
Firefighters placed it under control, and no one was hurt.
Then, the fire reignited just before 6 a.m. on Wednesday.
The fire department said it went into a defensive attack as crews inside the home made a mayday call.
One firefighter was taken to the hospital for non-fire-related injuries.
Action News does not have the firefighter's condition.
However, crews have once again placed the fire under control.