Chopper 6 was over what remained of the home on the 1500 block of Wayside Road.
The fire broke out just after 3:30 p.m. on Monday.
Crews arrived to find heavy flames and a partially collapsed roof.
Officials confirmed one person died, but no further details were available on the victim's identity.
The second victim was taken to an area hospital for unknown injuries.
The investigation into what caused the fire is underway.