It started just before 11:30 p.m. on Sunday when officers attempted to stop a pickup truck along the 4000 block of I Street for traffic violations.
Authorities say the driver sped off, leading police on a chase before the pickup crashed into multiple parked cars along the 4000 block of Castor Avenue.
Even a police vehicle was banged up in the wreck.
The two men who were in the truck were taken to area hospitals.
Investigators say the driver is wanted in connection with a homicide in Queen Anne's County, Maryland.
He is set to be extradited to Maryland to face murder charges.