It happened around midnight Tuesday on the 1700 block of Cecil B. Moore Avenue.
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Fire crews responded to the Hookah lounge, and found high levels of CO.
The 3-story building houses apartments above, and there is a day care next door.
Three people were evacuated from the lounge, and two above the day care.
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PGW was called to the scene to locate the source of the CO.
Fire crews ventilated the building.
There were no reports of any injuries.