The crash happened before 6 a.m. Tuesday in rainy conditions in the city's Tacony section.
Police tell Action News the crash involved two trucks. Other vehicles appeared to be involved as well.
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There were no immediate reports of injuries.
The crash brought rush hour traffic to a standstill for nearly an hour approaching Cottman Avenue.
By 6:30 a.m. the backup extended back past Woodhaven Road.
For a short time, police were diverting all southbound traffic off of I-95 at Woodhaven Road to ease the congestion.
By 7 a.m. images from Sky 6 traffic cameras showed the vehicles involved in the crash off to the side and all lanes of southbound I-95 traffic moving again.
Motorists were advised to expect continued delays in the area as traffic flow returned to normal.