Flames broke out around 11:30 p.m. on the 200 block of Virginia Avenue in Haddon Township, New Jersey.
Crews arrived to find heavy smoke coming from the first floor of the three-story home.
It took firefighters about 20 minutes to get the fire under control.
One person was injured and taken to the hospital. There is no word on the person's condition.
The cause of the fire remains under investigation.