The town hall will feature a live audience in Aston, Pennsylvania. The Democratic presidential nominee will field questions from audience members, according to CNN, who is moderating the event.
The audience of Pennsylvania voters will be composed of Democrats, Republicans and independents - all of whom confirmed they intend to vote in November and remain undecided or persuadable on the presidential candidate for whom they will cast a ballot. They were chosen from a pool of people identified by a nonpartisan research organization and CNN editorial producers working with local and state business groups, civic organizations, religious groups and universities, according to the network.
While CNN's Anderson Cooper will ask Harris some of the questions, the focus will be on questions from the voters. CNN says they did not edit nor offer any help in drafting the questions from audience members during the town hall.
With less than two weeks until Election Day, the presidential campaign has come down to a handful of states and the Commonwealth of Pennsylvania - the biggest prize, in terms of electoral votes - that will determine the next president of the United States.
Former President Donald Trump, the Republican presidential nominee, was invited but declined to participate in the town hall, CNN says.
Trump has stops planned in Georgia for Wednesday, another battleground state.
WPVI contributed to this report.