The incident happened before 5:30 a.m. Friday in the westbound lanes approaching the Schuylkill Expressway (I-76).
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Images from Sky 6 cameras showed the crash blocking the left lane approaching the ramp leading to the westbound Schuylkill Expressway.
PennDOT crews set up a detour directing traffic into the right lanes as crews worked to straighten the truck and clear the scene.
The traffic backup on I-676 West was extensive through much of morning rush hour.
Crews had finally cleared the scene by 8:00 a.m.
There were no reports of injuries.