The shots were fired along the 5400 block of Locust Street just after 8 p.m. Saturday.
When police arrived, they found a man in his 30s shot multiple times.
He was rushed to the hospital, where he later died.
A second man was also hurt and is listed in serious but stable condition.
Officers recovered two handguns at the scene.
They are also searching for a black vehicle that they believe may have been a getaway car.