The fire started shortly after 10:30 p.m. on the 400 block Feather Drive in the Wellington Woods development.
Firefighters arrived to heavy smoke pouring from the first floor of the row-home.
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The victim was found unconscious on the second floor.
He was rushed to Christiana Hospital's emergency room.
He died a short time later.
It took crews about twenty minutes to get the fire under control.
Damage is estimated at $50,000.
The fire marshal arrived on the scene to determine what sparked the blaze.