It happened at Aramingo Avenue and Margaret Street at 10 p.m. on Thursday.
The force from the collision knocked the victim out of his sneakers.
Police found the 37-year-old man lying on the ground and medics pronounced him dead at the scene.
Witnesses say the scooter rider ran a red light and collided with a Dodge Charger that had a green light.
The 22-year-old driving the car remained at the scene and is cooperating with investigators.