The incident happened shortly after 9:30 p.m. Wednesday along the 500 block of Ritner Street.
Police said someone opened fire, hitting a 19-year-old man in the head.
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The victim was pronounced dead at the scene.
Police say he had a gun in his hand.
A second man was rushed to Methodist Hospital with non-life-threatening injuries.
Police said a third man arrived at Thomas Jefferson University Hospital with a leg wound.
Both were listed in stable condition.
Investigators are working to determine what sparked the gunfire, and who was responsible.