It happened shortly before 8 p.m. Wednesday along the 2800 block of Huntingdon Street.
Police say someone opened fire at point-blank range on a 27-year-old man, striking him four times in the chest, twice in the back, once in the left side of his face and once in the right side of his neck.
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The victim was rushed to Temple University Hospital where he was pronounced dead at 8:08 p.m.
Based on witness information, police attempted to stop a vehicle they say was operating out of control at 25th and Cumberland.
Two men inside the vehicle bailed, a chase ensued and the suspects were taken into custody shortly after.
A weapon was recovered, police say, but no word on a motive.