Police were called to the area of 12th and Lycoming streets in Hunting Park just before 11 p.m.
Officers arrived to find a man in his 20s shot in the chest.
The man was pronounced dead at the hospital a short time later.
Police have not made any arrests, and no weapon has been recovered.
Detectives are working to determine if this incident may be connected to a similar murder last Saturday near the same exact location.