It happened around 2:45 p.m. on September 14 on the 1000 block of Arch Street.
Police say a 46-year-old man and a 51-year-old woman were both conducting public ministry when they were punched in the face.
Both victims were hospitalized for broken teeth, a broken nose, and a concussion, according to police
The suspects were last seen fleeing south on North 10th Street.
Anyone with information is asked to call police at 215-686-TIPS.