It happened around 4:30 p.m. Tuesday in the northbound lanes of I-476 near mile marker 63 in North Whitehall Township.
Investigators say a 39-year-old man was killed after his motorcycle collided with a tractor-trailer.
The motorcyclist was rushed to Lehigh Valley Hospital - Cedar Crest, where he was pronounced dead.
His identity has not been released.
No other injuries were reported.
The crash remains under investigation.