It happened around 10:40 a.m. Friday near Exit 6.
Three vehicles were involved, including a tractor-trailer, a pickup truck and a sedan.
Video from Chopper 6 showed medics tending to three people on stretchers.
Only one lane of traffic was getting by the scene.
The cause of the crash remains under investigation.
For the latest conditions on area highways, check 6abc.com/Traffic.