Video captured by ESPN showed the crowd sprinting off the field in North Philadelphia.
"Players are running off the field right now. There were some loud noises and it looks like players are evacuating the field right now," the announcer could be heard saying.
Just after 4:30 p.m. Friday, Temple sent out an alert saying there was gunfire near the 1300 block of North Broad Street, which is right near the field.
La Salle was playing St. Louis University, which issued a statement saying the game was canceled because of a shooting in the vicinity of the field.
No one on the field was injured.
"At this time, no shooter has been identified, and there are believed to be no victims. The shots were fired in the vicinity of an off-campus fast-food restaurant on Broad Street. The Philadelphia Police Department is leading this investigation," Jennifer Griffin, the vice president and chief for public safety at Temple said in a statement.
The game was called with 10 minutes of play remaining.
Anyone with information regarding this incident should contact Philadelphia police at 215-686-TIPS or Temple police at 215-204-1234.