Bimalbhai Patel and his wife, Jaiminaben Patel, of Bloomfield, were in the region for a religious retreat when flooding and mudslides swept through the area, destroying buildings and leaving many people unaccounted for.
Neighbors in Bloomfield said they were stunned to learn the couple is missing.
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The couple's 9-year-old son is safe with relatives in India, according to family members. Rescue operations remain underway as authorities search for survivors and those still missing.
The Patel family issued a statement pleading for help in locating the couple.
"My sister and brother-in-law are missing near the Nepal border, in an area affected by flooding. We urgently request the authorities to help locate and rescue them as soon as possible," according to the statement.
Bloomfield Mayor Jenny Mundell said the community is prepared to support the Patel family during the crisis.
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The growing list of missing people also includes New Yorkers Ramesh and Neelam Sharma. The Sharmas were on the pilgrimage when the flooding struck and have not been in contact with family members in New York since Wednesday morning, when they were near Tibet.
The United Sherpa Association is leading a fundraiser and put on a candlelight vigil for the hundreds lost and unaccounted for.
Queens community hold vigil for those missing after Nepal flooding
"We are trying to support those who have lost lives and are still alive out there," Chongba Lama Sherpa, with the United Sherpa Association.
Also among the Americans missing is a mother and 14-year-old daughter, who were visiting from New York. They were in contact with relatives an hour before the flooding hit.