It happened just after 11:15 a.m. at Torresdale Road and Sheffield Avenue in the city's Holmesburg section.
The chase began in Trenton, New Jersey, and crossed state lines into Pennsylvania. Sources say troopers were in pursuit of a vehicle that was possibly connected to a robbery.
The chase went down Interstate 95 before ending with the crash just a few blocks off the highway.
The car that was being chased was able to get away, sources added.
Chopper 6 was over the scene, where the trooper's vehicle could be seen stopped on a residential property after apparently crashing through a fence.
New Jersey trooper crashes in Philadelphia during pursuit: Sources
The trooper involved was not injured.
A damaged white SUV, which was not believed to be involved in the chase, could also be seen on the street.
No other details have been released at this time.
This article will be updated when more information becomes available.