The crash happened around 2:30 a.m. just past Exit 6 to the turnpike connector.
Four tractor-trailers and one car were involved, and at least one injury has been reported. There has been no word on who was injured or their condition.
Officials are working to clean up a fuel spill, as well as debris that could be seen scattered across the roadway.
Action News Traffic Reporter Matt Pellman said only the car lanes are available, meaning only three of six lanes are open for traffic at this time.
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The cause of the crash is under investigation.