It also left some drivers facing major delays while the roadway was shut down.
It happened around 5:15 p.m. in the southbound lanes of the Northeast Extension (I-476).
According to state police, the motorcyclist was the only person involved in the crash. The operator was transported to a hospital via a medical helicopter.
No further information has been provided on the incident.
All southbound lanes were blocked for roughly four hours after the crash.
The northbound lanes reopened just after 6:40 p.m. The southbound lanes reopened at approximately 9:30 p.m.
Anyone with information on this incident should contact local authorities.
Get real-time traffic updates at 6abc.com/traffic.