The 67-year-old Wolf discussed the treatment Wednesday during an appearance on WITF-FM radio in Harrisburg.
Wolf revealed in February that the cancer was detected early by his doctors, but he didn't give details at the time about how it would be treated.
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RAW VIDEO: Gov. Wolf announces prostate cancer
Wolf has said it wouldn't impair his ability to perform his duties as governor, and he's since kept up a brisk schedule of public appearances.
The Democrat took office in January 2015. He says the cancer was detected during a routine checkup.
He says his blood levels of PSA protein, or prostate specific antigen, had been rising for years.