It happened around 12:40 a.m. on Monday in the 2000 block of West Hunting Park Avenue.
Surveillance video shows the victim walking along the street.
As the video progresses, she can be seen crossing the street, and then starts running back across the four-lane roadway.
That's when the victim is struck by an oncoming vehicle moving at a high rate of speed.
The female victim was tossed approximately 30 feet before landing on the curb. The driver of the striking vehicle never slowed down.
People who live and work in this part of Nicetown say reckless driving along this stretch of road has been an issue for a long time.
"They run red lights. They don't stop at the stop signs. They don't have their turn signals on. So, it's a shame and you can't even cross the street without worrying about a car speeding by," said Akeem Gladney.
"They go right through this light and although they have a thing on the pole there for speeding, they don't care. They go right through the light and just keep going," said Walter Roseberry.
Police do not yet have a description of the striking vehicle.
The woman who was struck was not carrying any identification.
Anyone with information is asked to call or text Philadelphia police at 215-686-TIPS (8477).