It happened near East Chestnut Hill and Salem Church roads in Newark.
Police say the victim was hit by a large truck, which was badly damaged after the collision.
East Chestnut Road is closed at Salem Church Road due to the crash, according to state police.
There is no word yet on what led to the crash. Police have also not yet identified the victim.
For the latest in traffic around the area, use the 6abc Traffic Map.