The woman was struck by a white Sprinter van near North 5th Street and Chelten Avenue just before 7 a.m., according to police.
The victim was transported by medical personnel to Einstein Medical Center, where she later died.
Chopper 6 was over the scene, where a white MB Hardwood Floor van could be seen.
Police are investigating.
Action News has reached out to MB Hardwood Floor but have not heard back.