Brandywine Valley SPCA, ACCT Philly, Animal Adoption Center, Homeward Bound Pet Adoption Center and Humane PA are participating.
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Action News was there as some of the dogs that will be up for adoption at Brandywine arrived from Texas on Friday.
Every location will have $35 adoption fees for cats and dogs.
At some, like Brandywine Valley, that fee includes spaying, neutering and microchipping.
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The goal is to get at least 700 homeless pets into homes.
The event is being held this weekend, June 25 and 26.
For more information, visit BVSPCA.org.