The debate is set to begin at 7:00 p.m. at the Hilton Hotel on South Broad Street in Center City.
Democrat Jim Kenney and Republican Melissa Murray Bailey will be joined by two independents and a member of the Socialist Worker Party.
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The United Way is hosting the event.
Action News anchorwoman Tamala Edwards will moderate.
Online registration has closed, but walk-in audience members will be allowed if there is room.
The general election is November 3rd.