The change takes effect immediately, lowering the Centers for Disease Control and Prevention's recommended vaccines from 17 to 11.
Families have always been able to choose how to vaccinate their kids, but this latest drop in required vaccines has medical experts concerned, especially with the timing.
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"We're in the middle of respiratory season. It's very important for families to talk to their physician so they can get the most updated, science-backed information," said Dr. Delana Wardlaw, a family medicine physician.
Wardlaw said these new recommendations will create doubt and confusion for parents.
"We don't have any new data that suggests we should not give the flu vaccine, rotavirus, COVID, hepatitis vaccine, meningitis," noted Dr. Wardlaw.
She encourages all families to talk to their physician, someone who knows the scientific data and understands what the vaccines help prevent and why they are beneficial.
The White House said the updated schedule aligns with other countries. Remaining on the recommended list are measles, whooping cough, polio, tetanus, chickenpox and HPV.
Medical experts say these changes can put children at risk and that vaccines prevent diseases, complications and sometimes death.
"We will continue to continue with the same vaccines that have shown to be tried and true to save lives," said Dr. Wardlaw.
The Trump administration said families won't lose access to any vaccines and that insurance companies will continue to pay.