Officers responded to reports of gunfire around 12:55 a.m. Saturday on the 1800 block of East Clementine Street.
Police say they found an adult male suffering from a gunshot wound to the back.
The victim was taken to Temple University Hospital by police where he was pronounced dead a short time later.
No arrests have been announced, and no weapon has been recovered.
Anyone with information is asked to contact police at 215-686-TIPS.