It happened at the intersection of Frankford and Grant avenues just after 5:30 a.m. Saturday.
According to police, a 2008 Lexus was traveling northbound on Frankford Avenue when it entered the intersection and struck the police vehicle.
The driver of the police vehicle was transported to Jefferson-Torredale Hospital and is in stable condition, officers say.
The driver of the Lexus reportedly refused medical treatment at the scene.
Police have not stated whether charges will be filed in this case. There is also no word yet on the injured officer's identity.