It happened around 1 a.m. Saturday on the 600 block of North Preston Street.
Investigators tell Action News they found a 26-year-old man shot in the foot and a woman shot in the head.
The man was taken to the hospital where he is listed in stable condition. The woman is currently in critical condition.
No arrests have been made and no weapons were recovered.
This is an ongoing investigation with the Shooting Investigation Group.