Sgt. Brian Schellman says officers responded Thursday afternoon to a report of a shooting at a north St. Louis County home.
He says officers arrived to find the 16-year-old boy dead inside.
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Police believe the teen made it inside the home on his third attempt to break in and say the 11-year-old shot him in the head.
Schellman says a 4-year-old girl was also inside. Neither she nor the 11-year-old was hurt.
Authorities have not identified the second suspect, who they say fled but was found a short time later.
Schellman says the children's mother wasn't home during the incident but is cooperating with an investigation.