It happened just after midnight Sunday at 21st and Conlyn streets.
Police say one of the victims, a 21-year-old man, was found inside a car with a gunshot wound to the head.
Medics rushed him to the hospital in critical condition.
Authorities say a 20-year-old passenger, who was shot in the arm, was taken to the hospital in stable condition.
So far, no word on any arrests or what led up to the gunfire.