The incident happened around 8:30 a.m. Tuesday on the 1400 block of Wayne Street.
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When officers arrived on the scene, Patricia Torres, 44, was found dead from multiple stab wounds, according to Reading police.
The victim's husband, 51-year-old Jose Torres, was arrested and charged with first and third-degree murder.
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Investigators say the homicide appears to be the result of a domestic incident.
It's still unclear what sparked the attack.