It happened just before 6:30 p.m. on the highway between Bartram Avenue and North Broad Street.
According to police, two people were transported to a local hospital with injuries. There is no word yet on their conditions.
Authorities have not said what may have led to the collision.
I-95 North was temporarily closed between Exit 12 (Pa. 291 Cargo City) and Exit 17 (Pa. 611 North Broad / Pattison Avenue).
The roadway was reopened just before 9:30 p.m.
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