Lottery players' next chance to win the big prize will come on Saturday when another drawing will be held.
If a player wins Saturday night, they will have the choice between annual payments worth an estimated $1.5 billion or an immediate $686.5 million lump sum payment.
Wednesday night's winning numbers are: 25, 33, 53, 62, 66 and the Powerball is 17. The Power Play is 4x.
Nationwide, six tickets matched all five white balls to win $1 million prizes. The winning Match 5 tickets were sold in Connecticut, Pennsylvania, Tennessee and three in New York.
The Powerball jackpot was last hit on Sept. 6 by two tickets in Missouri and Texas that split a $1.787 billion prize.
According to Powerball, the odds of winning the jackpot are 1 in 292.2 million.
ABC News contributed to this report.