The incident occurred Saturday night inside a residence hall off Eagle Road on the university's campus, according to police.
Sources said a college-aged female reported being sexually assaulted by several male suspects. Investigators are interviewing those involved.
Students at the Christian college in Radnor Township described shock and frustration as details of the investigation emerged.
"Pretty horrible to hear," said Thomas Hellenbrand, a college student in Radnor Township.
Emily Myers, also a student in the township, said the report reflects a larger issue for women.
"Just the violence that women face on an everyday basis. It's really disheartening as a woman," Myers said.
Eastern University released a statement saying it is cooperating with police.
Some students said colleges should take additional steps to prevent violence and educate students.
Myers emphasized the need for institutions to support those who come forward.
"It's honestly about creating a culture where victims feel heard and feel like they have outlets to report and be taken seriously," she said.
No charges have been filed at this point. Sources said police anticipate multiple people will be charged as the investigation continues.
Full statement from Eastern University:
"The safety of our students is top priority at Eastern University. The University is aware of the reported incident and is taking this matter very seriously. We are cooperating fully with the Radnor Police Department, which is actively investigating the matter. The University is acting in accordance with state and federal laws and institutional policy to support the students involved. All questions related to the investigation should be directed to the Radnor Police Department. Fostering a safe and respectful environment is central to our mission. As a Christian University, we are deeply committed to the well-being of all students, and provide a wide variety of supportive services."