The crash happened near N. Springfield School Road north of Kenly, in Wilson County, North Carolina.
Inside the RV were 5 people, 28 snakes, 2 tortoises, 5 Bearded Dragons, 2 dogs and 1 cat.
"In 19 years, I've never seen anything like this," a North Carolina State Highway Patrol trooper told WRAL News.
At least one of the snakes was a small, highly venomous viper, which became loose in the RV during the crash. The owner was able to catch the snake prior to EMS workers arriving.
No one in the RV was hurt; all of the animals survived.
"I have a bunch of reptiles, I do reptile expos," said the man driving the RV. "I had some venomous snakes get loose in the camper when this accident happened so I had to get the snakes before the EMS personnel came in because I didn't want to put them at risk. I successfully got them."
The RV was towing a Jeep Cherokee, which was crushed by the impact and forced into the rear bedroom of the RV where one of the family's sons was sleeping at the time; he was not seriously injured.
The driver of the truck was seriously injured and transported to WakeMed in Raleigh. Authorities believe he fell asleep at the wheel prior to the collision.
It is unclear whether he will face any charges.
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