It happened on Monday around 9:03 p.m. in the area of Blackman Road between Brookside Drive and Meadow Drive in Egg Harbor Township.
Police say 38-year-old Oriel Dixon, of EHT, was traveling northbound on Blackman Road in a 2006 Mercury Mountaineer when she allegedly crossed the center line.
While traveling the wrong direction, authorities say she then struck 72-year-old Joseph Natale who was inside a 2015 Honda CRV with his 28-year-old passenger.
Natale died at the hospital. His passenger was also hospitalized for unknown injuries.
Police say Dixon was arrested for driving while impaired. According to investigators, she also had a juvenile in her vehicle. Both people were treated for non-life-threatening injuries.
Additional charges are possible as the investigation continues, police said.