Miguel Colon, 22, turned himself in at police headquarters on Monday.
Police say Colon was behind the wheel of a white 2006 Infiniti when he struck 19-year-old Josephine Rivera and her 2-year-old son, David Alicea, while driving southbound on Mascher Street near Lehigh Ave.
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The mother and son were crossing the street when they were hit.
Police say Rivera, who was treated and released, remained by her son's bedside until he died a few days later.
The car was recovered a few days after the incident.