It happened just before 7:30 p.m. on the 2700 block of North Thatcher Street.
At the scene, police say they found a 17-year-old, an 18-year-old, and a 21-year-old suffering from gunshot wounds.
All three were transported to an area hospital, where the 18-year-old later died.
There is no word yet on his identity.
The 17-year-old is in critical condition and the 21-year-old is stable, according to police.
Officers say the shooting is still under investigation. Anyone with any information is asked to contact the police at 302-576-3652.