It happened before 12 a.m. Monday on Moore Street near South Hollywood Street.
Officers arrived to find the 17-year-old boy shot multiple times.
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They put him a police cruiser and took him to Penn Presbyterian Medical Center, where he remains in critical condition.
Witnesses told police they say a dark-color vehicle fleeing the scene after the gunfire erupted.
RAW VIDEO: Teen shot multiple times
Investigators were checking for surveillance video that may have captured the incident.
Stay with Action News and 6abc.com for more information as it becomes available.