The incident happened at 11:37 a.m. Thursday at East Ferry and River roads in Morrisville.
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Authorities say a water treatment plant worker observed the black Honda Accord enter the river. He then immediately jumped into the river and successfully removed the woman inside the vehicle and brought her to shore.
RAW VIDEO: Car plunges into Del. River
Arriving police officers say the vehicle was submerged up to the door handles, approximately 15-20 feet into the river.
The victim was transported to an area hospital for treatment.