Authorities say the truck slammed into Club 2120, a gentlemen's club attached to the Riviera Motel in Pennsauken.
Chopper 6 was over the scene on the 2100 block of Route 73 just before 10:30 p.m.
The truck tore a hole into the side of the building.
It is unclear what led up to the crash.
Authorities did not report any injuries.