It happened around 8:30 a.m. on New Bridge Road, at the bridge crossing Brandywine Creek.
New Castle County Paramedics and the Talleyville Fire Company responded to the area for a large commercial vehicle that had fallen off the roadway after crashing through a barrier wall of a bridge.
Chopper 6 was over the scene, where you could see that the truck was in a ditch below the bridge.
Chopper 6 over truck crash in Wilmington, Delaware
Officials say the 27-year-old driver was taken to a nearby hospital in critical condition.
The incident is currently under investigation by the Delaware State Police.