The Chevy van was traveling north on I-295 around 11:20 a.m. Wednesday when it struck the rear of the tractor-trailer.
The van driver suffered non-life-threatening injuries.
Video from Chopper 6 showed debris that was left all over the highway.
The truck driver was not hurt.
The crash remains under investigation.
For the latest conditions on area highways, check 6abc.com/Traffic.