The victim has been identified as 23-year-old Keith Allan Ream of Coatesville.
It happened around 11 p.m. Wednesday night in East Caln Township.
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Authorities say Allan was traveling westbound in the eastbound lanes when he collided with a tractor-trailer.
Allan was ejected from his vehicle.
No other injuries were reported.
The eastbound Route 30 Bypass was closed as police investigated. It reopened around 8:30 a.m. Thursday.
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