The collision happened around 2:24 p.m. near 8th and Washington streets.
According to investigators, a 29-year-old Newark man driving the school bus allegedly ran a red light and struck another vehicle.
Police said a 39-year-old woman and an 8-year-old girl who were inside the vehicle were taken to a hospital in stable condition.
Four children aboard the school bus were also transported to a hospital for evaluation of minor injuries, authorities said.
The bus driver was issued traffic summonses in connection with the crash.
Stay with Action News as we continue to follow this developing story.