The fire broke out around 4:45 a.m. Friday in the 2600 block of S. Mildred Street.
Officials say three people, two women and a child, were rescued from the home. One of the victims has since died, according to police.
Family members tell Action News that the victims are a 49-year-old mother and her 4-year-old daughter. There has been no word on who the third victim is.
"My niece and her mother were trapped in the basement, so we drove here real quick. My fiancé is over there at the house, checking everything out. And I was just trying to find her. That's really the just of everything I know," the relative said.
Video obtained by Action News shows first responders rushing the child on a stretcher to a nearby ambulance before being taken to the hospital.
Part of Oregon Avenue is closed due to the response.
Officials say they were able to contain the fire within 15 minutes of arriving on the scene. They also said there were no working smoke alarms in the home.
It is unclear how many homes may have been damaged by the fire.
The cause of the fire is unknown.